喬娟
喬娟，女，理學博士，教授，博士生導師，北京石油化工學院新材料與化工學院生物制藥專業責任教授。2002年畢業于河北大學化學與環境科學學院，獲學士學位；2005年畢業于河北大學化學與環境科學學院，獲碩士學位；2010年畢業于中國科學院化學研究所，獲博士學位；2010-2022任中科院化學所助理研究員/副研究員；2016-2023兼任中國科學院大學化學科學學院崗位教師；2017- 2018在美國馬薩諸塞大學阿默斯特分校國家公派訪學。
從事聚合物的制備及生物藥物分析應用研究。作為項目負責人承擔和完成國家及北京市自然科學基金項目5項；以第一作者/通訊作者發表SCI論文27篇，申請專利3項；參編專著2部；獲中國分析測試協會科學技術獎一等獎2項。兼任北京色譜協會理事以及多個國內外專業期刊審稿人。
I. 主要研究工作
1. 毛細管電泳手性藥物分析研究
2. 溫敏熒光聚合物的制備及其細胞內溫度成像應用研究
3. 靶向識別/原位可控聚合物酶反應器的制備及其蛋白酶解研究
II. 獎勵與榮譽
1. 齊莉，喬娟，木肖玉，李楠，陳義. 構建聚合物分子溫度計及其細胞成像應用研究，中國分析測試協會科學技術獎一等獎，2016年。
2. 齊莉，喬娟，張海枝，姚春荷，沈瑩，木肖玉，張榮月，辛培勇，魏曉奕，李雅萍，陳義. 基于蛋白質及手性氨基酸分析的生物色譜新方法研究，中國分析測試協會科學技術獎一等獎，2012年。
III. 承擔科研項目
1. 北京市自然科學基金面上項目：神經遞質對映體的手性共價有機框架毛細管電泳分離研究（2242005），項目負責人
2. 國家自然科學基金面上項目：靶向識別細胞表面糖蛋白及其原位可控酶解（22074148），項目負責人
3. 國家自然科學基金重大研究計劃培育項目：情感和記憶過程中溫度與神經遞質變化研究（91732103），項目負責人
4. 國家自然科學基金面上項目：刺激響應型聚合物多孔膜酶反應器的制備及其蛋白酶解研究（21475137），項目負責人
5. 國家自然科學基金青年基金項目：溫敏熒光嵌段聚合物的制備及其在細胞內的溫敏應用研究（21205125），項目負責人
6. 北京石油化工學院致遠科研基金：NIR-II熒光聚合物及其亞細胞器溫度變化研究（2024004），項目負責人
7. 化學所培育項目：熒光溫敏聚合物制備及Ca2+通道調控細胞溫度變化研究（CMS-PY-201355），項目負責人
8. 分子科學中心創新項目：整體柱酶反應器及氨基酸代謝的微流控芯片電泳研究（CX-201023），項目負責人
IV. 代表性學術論文
1. Shidi Zhang, Li Qi,* Rui Yao, Zhenwen Zhao, Fangna Gu, Juan Qiao*, Thermo-Responsive Polymer/Cerium?Gold Nanoparticle-Decorated UiO-66-NH2 Nanozymes for Colorimetric Sensing of Captopril, ACS Applied Nano Materials, 2026, 9, 3792-3801.
2. Bowen Zhou, Li Qi*, Yutong Liu, Yushi Zhou, Juan Qiao*, Confining AuNPs on mesoporous MOFs towards enhanced catalytic activity for visual monitoring of L-cysteine, Inorganic Chemistry Communications, 2026, 187, 116404.
3. Meng Yang, Qiong Wang, Xinle Wang, Chuanfang Chen, Cai Liu, Juan Qiao*, Encapsulating gold nanoclusters into zinc-glutamate metal organic frameworks for ferric ions detection in zebrafish embryos, Microchimica acta, 2026, 193, 187.
4. Yan Zhang, Zexi Yu, Xiaotong Zhu, Rongyue Zhang, Nan Li, Min Wang, Juan Qiao *. γ-cyclodextrin based metal organic framework as micellar electrokinetic chromatography additive for the chiral separation of dansylated amino acids, Journal of Chromatography B, 2026:1268, 124839.
5. Shufan Ge, Xiaotong Zhu, Chuanfang Chen, Rongyue Zhang, Min Wang, Nan Li, Xiaonan He, Juan Qiao*, Fluorescence polymer thermometer for the real-time mitochondrial temperature imaging of zebrafish embryos and larvae, Dyes and Pigments, 2026, 246, 113309.
6. Xiaotong Zhu, Xinyu Li, Haozhe Liu, Rongyue Zhang, Nan Li, Min Wang, Xiaonan He, Yunliang He, Juan Qiao*, A fluorescence-colorimetric dual-signal sensing platform based on arginine@ATT-AuNCs for ascorbic acid metabolic analysis in mice, Microchemical Journal 2025, 218, 115777.
7. Meng Yang, Xiaotong Zhu, Rongyue Zhang, Zhenwen Zhao, Li Qi, Min Wang, Nan Li, Juan Qiao*, Construction of AuNCs@MOF and Lead Ions Metabolic Analysis in Rat Serum, Inorganic Chemistry Communications, 2025, 178, 114517.
8. Xiaotong Zhu, Xinyu Li, Li Qi, Rongyue Zhang, Nan Li, Xiaonan He, Juan Qiao*, Protein@AuNPs synthesized by microfluidic droplet system and application in Cu(II) and L-Cysteine sensing[J], Chemical Research in Chinese Universities, 2025, 41, 131-137.
9. Xiaotong Zhu, Rongyue Zhang, Yucong Wang, Hongxia Jia*, Juan Qiao*, Fluorescence-enhanced MOF-encapsulated AuNCs for highly sensitive detection of melanin[J], Inorganic Chemistry Communications, 2024, 113226.
10. Juan Qiao, § Cheng Cheng, § Dan Li, Li Qi*, Thermo-responsive polymer-modified metal–organic frameworks as soft–rigid enzyme-reactors for enhancement of enzymolysis efficiency using a controllable embedding protocol[J], Journal of Materials Chemistry B, 2023, 11, 6428.
11. Juan Qiao,§ Qian Ma,§ Cheng Cheng, and Li Qi*, Fabrication of Dual-Stimuli-Responsive Polymer Vesicles for Regulation of Enzymolysis Efficiency in A Cascade Reaction[J], Chemistry An Asian Journal, 2023, 18, e202300285.
12. Juan Qiao,§ Xinya Zhang,§ Cheng Cheng, Li Qi*, Thermo-sensitive Porous Polymer Membrane-immobilized Cellulose as a Switchable Enzyme Reactor for Tuning Its Enzymolysis via Variation Temperature[J], Chemical Research in Chinese Universities, 2023, 39(6), 992-997.
13. Juan Qiao, Qian Ma, Xiangfei Li, Li Qi*, Redox-responsive polymer nanoreactors based on methionine sulfoxide for monitoring cell adhesion [J]. Analytical Chemistry, 2022, 94, 11807-11812.
14. Juan Qiao, Xiangfei Li, Li Qi*, Fluorescent polymer-modified gold nanobipyramids for temperature sensing during photothermal therapy in living cells [J]. Chinese Chemical Letters, 2022, 33, 3193-3196.
15. Juan Qiao, Yuying Song, Chuanfang Chen, Li Qi*, In situ determination of sialic acid on cell-surface with pH-regulated polymer enzyme nanoreactor [J]. Analytical Chemistry, 2021, 93, 7317-7322.
16. Juan Qiao, Deyu Wu, Yuying Song, Wenliang Ji, Qingwei Yue, Lanqun Mao, Li Qi*, Simultaneous monitoring of intracellular temperature and norepinephrine variation by fluorescent probes during norepinephrine reuptake [J]. Analytical Chemistry, 2021, 93, 14743-14747.
17. Juan Qiao, Lili Liu, Ji Shen, Li Qi*, Enzyme immobilization on a pH-responsive porous polymer membrane for enzymatic kinetics study [J]. Chinese Chemical Letters, 2021, 32, 3195-3198.
18. Juan Qiao, Li Qi*, Recent progress in plant-gold nanoparticles fabrication methods and bioapplications [J]. Talanta, 2021, 223, 121396.
19. Juan Qiao, Han Wu, Huan Wei, Lanqun Mao, Tie Wang, Li Qi*, Selective capture and in-situ controllable detection of D-glucose in cerebral systems [J]. Analytical Chemistry, 2020, 92, 4445-4450.
20. Juan Qiao, Yoon-Ho Hwang, Dong-Pyo Kim, Li Qi*, Simultaneous monitoring of temperature and Ca2+ concentration variation by fluorescent polymer during intracellular heat production [J]. Analytical Chemistry, 2020, 92, 8579-8583.
21. Juan Qiao, Junfang Jiang, Lili Liu, Ji Shen, Li Qi*, Enzyme reactor based on reversible pH controlled catalytic polymer porous membrane [J]. ACS Applied Materials & Interfaces, 2019, 11, 15133-15140.
22. Juan Qiao, Qianrong Liu, Han Wu, Huiwu Cai, Li Qi*, Non-enzymatic detection of serum glucose using a fluorescent nanopolymer probe [J]. Microchimica Acta, 2019, 186, 366.
23. Juan Qiao, Liping Zhao, Lili Liu, Li Qi*, L-Glutaminase enzyme reactor based on porous bamboo sticks and its application in enzyme inhibiters screening [J].Talanta, 2019, 205, 120126.
24. Wenya Feng, Juan Qiao*, Dan Li, Li Qi*, Chiral ligand exchange capillary electrochromatography with dual ligands for enantioseparation of D,L-amino acids [J].Talanta, 2019, 194, 430-436.
25. Juan Qiao, Chuanfang Chen, Dihua Shangguan, Xiaoyu Mu, Shutao Wang, Lei Jiang*, Li Qi*, Simultaneous monitoring of mitochondrial temperature and ATP fluctuation using fluorescent probes in living cells [J]. Analytical Chemistry, 2018, 90, 12553-12558.
V. 發明專利和軟件著作權
1. 喬娟，曹俊陽，張競丹，李浩玉，張榮月，一種聚合物修飾環糊精MOFs材料及其制備方法和毛細管電泳手性分離方法，中華人民共和國發明專利, ZL202311609129.8
2. 齊莉, 沈吉, 喬娟, 刺激響應聚合物基質D-氨基酸氧化酶反應器的制備及其酶解效率調控方法，中華人民共和國發明專利, ZL202110463264
3. 齊莉, 喬娟, 李雅萍, 木肖玉, 一種固定化L-天冬酰胺酶反應器，中華人民共和國發明專利, ZL201210137793.2
VI. 出版著作
1. 王可，喬娟，《光學探針與傳感分析》馬會民主編 (第11章), 2020, 448-472
2. Juan Qiao, Li Qi. Design and preparation of stimuli-responsive AIE fluorescent polymers-based probes for cells imaging, Handbook of Aggregation, 2022
VII. 研究生指導情況
在讀研究生10名，畢業研究生1名，輔助指導多名聯培碩士生，教授《高級生物化學》研究生必修課程
聯系郵箱：qiaojuan@bipt.edu.cn
